منابع مشابه
Effect of p-hydroxyacetanilide on liver cancer induction by N hydroxy-N-2-fluorenylacetamide.
We explored, in rats, the conditions underlying the induction of liver tumors by ./V-hydroxy-./V-2-fluorenylacetamide (N-OH-FAA) in terms of the participation of an ultimate carcinogen in the form of the sulfate ester. Male rats were fed 2 dose levels, i.e., 0.0213%(0.89 mmole/kg) and 0.032%(1.34 mmoles/kg) of N-OH-FAA in the diet, with or without 0.89% (59 mmoles/kg) p-hydroxyacetanilide, and ...
متن کاملImmunosuppression in primary liver and colon tumor induction with N-hydroxy-N-2-fluorenylacetamide and azoxymethane.
The question was examined as to whether immunosuppression in a rat model system would affect the carcinogenic processes leading to tumors in the liver and the large bowel. The protocols were designed to detect an increased incidence or a shorter latent period stemming from a change in immune status. Groups of rats were given injections prior to initiation of the carcinogen regimen and continuou...
متن کاملInhibitory Induction Effect of Disulfiram on Rat Mammary by N-2-Fluorenylacetamide and on Its Conversion to N-Hydroxy-N-2-fluorenylacetamide
The effect of an antioxidant, disulfiram (DSF), on the carclnogenlcltles of N-2-fluorenylacetamlde (2-FAA) and Nhydroxy-N-2-fluorenylacetamlde (N-OH-2-FAA) was examined. DSF given In a diet at a concentration of 0.9% for 1 week before and throughout the carcinogen treatment (0.1 mmol/kg 3 times a week for 4 weeks) reduced the Incidence of mammary tumors Induced with 2-FAA by 50% and extended th...
متن کاملN-(6-Hydroxy-2-fluorenyl) acetamide, a urinary metabolite after intraperitoneal injection of N-2-fluorenylacetamide into rats.
In the solvent system used in this laboratory (1) for the resolution of the urinary metabolites of the carcinogen N-2-fluorenylacetamide,’ the mobility of synthetic N-(6-hydroxy-2-fluorenyl)acetamide (2) on paper chromatograms was similar (RF 3.4 to 14.5)2 to that of N-(7-hydroxy-2-fluorenyl)acetamide (RF 3.4 to 15.4), a known and quantitatively important metabolite of 2FAA (cf. (3)). Prelimina...
متن کاملEffects of adrenocorticotropic hormone and growth hormone on the metabolism of N-hydroxy-N-2-fluorenylacetamide and on physiologic parameters.
The effects of large doses of adrenocorticotropic hormone (ACTH) and of growth hormone on physiologic parameters and on the metabolism of N-hydroxy-JV^-fluorenylacetamide (N-OH-FAA) were investigated in Fischer male rats. ACTH, 96 or 80 units, and growth hormone, 12 or 10 mg, were injected s.c. daily for 10 consecutive days into animals prefed either control diet or the N-OH-FAA-containing diet...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1969
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63526-4